TCA cycle off, ATF4 on for metabolic homeostasis

Durga Mahor, Rishikesh Pandey,Vinay Bulusu

Trends in Biochemical Sciences（2022）

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摘要

Tricarboxylic acid (TCA) cycle is a major hub for catabolic and anabolic reactions, yet cellular metabolic adaptations following its inhibition are largely unknown. Using multi-tiered omics approaches, Ryan et al. have shown convergent activation of the integrated stress response (ISR) through ATF4-mediated rewiring of cellular amino acid and redox metabolic pathways.

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关键词

TCA cycle,fumarate hydratase,succinate dehydrogenase,glutathione synthesis,integrated stress response,ATF4

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