Integration of genetic colocalizations with physiological and pharmacological perturbations identifies cardiometabolic disease genes

Michael J Gloudemans,Brunilda Balliu,Daniel Nachun,Theresia M Schnurr,Matthew G Durrant,Erik Ingelsson,Martin Wabitsch,Thomas Quertermous,Stephen B Montgomery,Joshua W Knowles,Ivan Carcamo-Orive

Metabolism（2022）

引用 6|浏览23

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摘要

Our use of transcriptional responses under metabolic perturbations to contextualize genetic associations from our custom colocalization approach provides a list of likely causal genes and their upstream regulators in the context of IR-associated cardiometabolic risk.

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关键词

Cardiometabolic disease,Colocalization,Differential expression,Genome-wide association studies,Insulin resistance,Integrative gene prioritization,Perturbation experiments,Type 2 diabetes

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