P2X4 Inhibition reduces microglia inflammation and apoptosis by NLRP3 and improves nervous system defects in rat brain trauma model

Wei He, Qian Wang,Weiping Sha,Liming Wang,Di Li,Gang Chen

Journal of Clinical Neuroscience（2022）

引用 7|浏览3

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摘要

•The purinergic receptor P2X4 is an adenosine triphosphate (ATP)-gated cation channel, which plays an essential role in regulating various biological activities in the organism.•This study was designed to investigate the potential role and mechanism of P2X4 in the traumatic brain injury (TBI) rat model.

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关键词

P2X4,NLRP3,Inflammation,Apoptosis,Neuroprotection,Traumatic brain injury

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