A novel method for miRNA detection based on target-triggered transcription of a light-up RNA aptamer

Seoyoung Lee,Hansol Kim,Yeonkyung Park,Hyun Gyu Park

Chemical Communications（2022）

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摘要

We herein describe a novel method for miRNA detection based on target-triggered transcription of a light-up RNA aptamer (TTRApt), consequently producing a highly enhanced fluorescence signal through specific binding of a light-up RNA aptamer to the corresponding dye. Using this strategy, we successfully identified target miRNA down to 59.4 aM with excellent specificity.

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关键词

MicroRNAs

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