Recent Trends in Ibuprofen and Ketoprofen Electrochemical Quantification - A Review

Non-steroidal anti-inflammatory drugs are intensively manufactured, used, and regulated. However, these compounds incur toxic effects on gastrointestinal, cardiovascular, and renal systems when administered in high doses for extended periods. Additionally, once these drugs reach the ecosystems through various pathways, they become environmental contaminants and raise ecological concerns. Traditional detection methods proposed for non-steroidal anti-inflammatory drugs detection encompass certain limitations. In this context, the need for simple, cost-effective, sensitive, and selective detection methods that could improve the quality of analysis led the attention of the scientific community toward electrochemical sensors. The lowest limit of detection of ibuprofen (33.33 x 10(-12) mu mol L-1) was recorded for a sensor based on ibuprofen specific aptamer bound with nitrogen-doped graphene quantum dots and gold nanoparticles nanocomposite modified glassy carbon electrode using differential pulse voltammetry, while the lowest limit of detection reported for ketoprofen was 0.11 mu mol L-1 when differential pulse voltammetry was used. This review focuses on the construction, analytical performances, and applicability of electrochemical sensors developed for ibuprofen and ketoprofen determination. This work covers 24 articles published between 2016 and 2022.