Zebrafish: An In Vivo Screening Model to Study Ocular Phenotypes.
Translational vision science & technology（2022）
Abstract
The proposed pipeline was applied successfully in zebrafish and can be used for future genetic screenings of candidate genes. While validating our pipeline, we found a close resemblance between the ocular manifestations in the zebrafish mutants and patients harboring mutations in PRSS56 and FBN1. Our results support the validity of our pipeline and highlight the potential of zebrafish as an animal model for in vivo screening of candidate genes for ocular diseases.
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Key words
refractive error, FBN1, PRSS56, Marfan syndrome, nanophthalmos
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