Infection of non-cancer cells: A barrier or support for oncolytic virotherapy?
Molecular Therapy - Oncolytics(2022)
Abstract
Oncolytic viruses are designed to specifically target cancer cells, sparing normal cells. Although numerous studies demonstrate the ability of oncolytic viruses to infect a wide range of non-tumor cells, the significance of this phenomenon for cancer virotherapy is poorly understood. To fill the gap, we summarize the data on infection of non-cancer targets by oncolytic viruses with a special focus on tumor microenvironment and secondary lymphoid tissues. The review aims to address two major questions: how do attenuated viruses manage to infect normal cells, and whether it is of importance for oncolytic virotherapy.
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Key words
oncolytic virus,infection of non-cancer cells,cancer therapy,tumor microenvironment,secondary lymphoid tissues
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