Protective effect and mechanism of loganin and morroniside on acute lung injury and pulmonary fibrosis

In this study, we detected the effects of loganin and morroniside (two iridoid glycosides extracted from Cornus officinalis) on acute lung injury and pulmonary fibrosis. As shown by HE staining in Fig. A, loganin and morroniside relieved the pathological symptom of lung tissue in LPS-induced acute lung injury, the pulmonary edema was reduced. Besides, in Fig. B, masson staining showed that loganin and morroniside relieved bleomycin induced pulmonary fibrosis in a concentration dependent manner. This study may provide theoretical basis for the development of new clinical drugs in treating ALI and pulmonary fibrosis.