Mitochondria-derived reactive oxygen species are involved in renal cell ferroptosis during lipopolysaccharide-induced acute kidney injury

•Fer-1 attenuated LPS-induced renal lipid peroxidation, characteristic mitochondrial damage and renal cell death.•Mitochondria-derived ROS contribute, at least partially, to renal cell ferroptosis during LPS-induced AKI.•Mitochondria-targeted antioxidants may be potential therapeutic agents for sepsis-induced AKI.