Mitochondria-derived reactive oxygen species are involved in renal cell ferroptosis during lipopolysaccharide-induced acute kidney injury
International Immunopharmacology(2022)
Abstract
•Fer-1 attenuated LPS-induced renal lipid peroxidation, characteristic mitochondrial damage and renal cell death.•Mitochondria-derived ROS contribute, at least partially, to renal cell ferroptosis during LPS-induced AKI.•Mitochondria-targeted antioxidants may be potential therapeutic agents for sepsis-induced AKI.
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Key words
Acute kidney injury,Ferroptosis,Mitochondria-derived reactive oxygen species,Mitochondria-targeted antioxidants
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