Study of Antioxidant Activity of New Compounds with 1,3-Thiazin-2,6-Dione and Pyrrolidine Fragments

V. P. Osipova,M. A. Polovinkina,M. N. Kolyada,A. D. Osipova,N. T. Berberova,A. V. Velikorodov

Doklady Chemistry（2022）

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Abstract

Antioxidant activity of new compounds with 1,3-diazin-2,6-dione and pyrrolidine fragments in comparison with 2,6-di- tert -butyl-4-mercaptophenol has been studied in the model system of adrenaline autooxidation in alkaline medium in DPPH, NBT, and CUPRAC tests. In the series of studied compounds, a leader has been revealed, which shows moderate antiradical activity toward DPPH radical, prevents accumulation of toxic products of adrenaline quinoid oxidation, and exhibits higher efficiency as one-electron Cu 2+ reducing reagent as compared with known antioxidants, trolox and 2,6-di- tert -butyl-4-mercaptophenol.

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Key words

1,3-thiazin-2,6-dione fragment, pyrrolidine, DPPH test, CUPRAC test, NBT test, antioxidant activity, adrenaline, xanthine oxidaze, superoxide anion radical

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