Anti-Tobacco Mosaic Virus Chromone Derivatives from the Stems of Nicotiana tabacum

Two new compounds ( 1 and 2 ), together with five known ( 3–7 ) chromone derivatives, were isolated from the stems of Nicotiana tabacum (a gene-edited mutant cultivated by Yunnan China Tobacco Industry Co., Ltd.). Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 , 2 , and 7 were tested for their anti-tobacco mosaic virus (anti-TMV) activity. The results showed that compound 1 , 2 , and 7 exhibited high anti-TMV activities with inhibition rates of 38.4, 43.5, and 33.6% at the concentration of 20 μM. These rates are higher than that of positive control.