Functional Polyelectrolyte Coatings on Polymeric and Magnetic Colloidal Particles for Antifouling and Non-Toxic Bioconjugate Nanoparticles

In this paper, we used H-bonding and/or electrostatic force-driven polyelectrolyte multilayer (PEM) coatings on the surface of magnetic (paramagnetic and ferromagnetic) colloidal particles to prevent irreversible coagulation and introduce biochemical moieties. Polyacrylamide (PAAm), poly(acrylic acid) (PAA), and a cationic modified cyclodextrin polymer P( β -CyD) were used for the coating. Through the chemical groups of the PEM coating the RGD-peptide ligand was introduced on the magnetic particles, which enhanced strong specific cell-magnetic particle interactions. P( β -CyD)-containing surface-coated magnetic particles also show great potential in cell culture. These functional PEM coatings on magnetic colloidal particles may have great potential in bio-applications including targeted intracellular drug delivery.