Rhamnolipid-assisted black phosphorus nanosheets with efficient isolinderalactone loading against drug resistant Helicobacter pylori

Yanqiang Huang,Rujia Li,Yuanyuan Dai,Chun Qin, Jikai He,Shixian Yang,Tengqi Wang,Yujie Su,Lizhou Jia,Wei Zhao

Materials & Design（2022）

Cited 9|Views8

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Abstract

•A multi-functional RHL@BP/ISL nanocomposite characterized with BP protection, high capability of drug loading, mucus layer penetration, acid responsive and NIR control release of payloads was developed.•Oral formulation with simply prepared procedures.•Efficient NIR and acid-promoted release of ISL.•Preeminent activity against drug-resistant HP separated from patients.

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Key words

H. Pylori,Drug resistance,Black phosphorus,Isolinderalactone,Antibacterial,Photothermal therapy

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