Polyphosphate-Based Hydrogels as Drug-Loaded Wound Dressing: An In Vitro Study
ACS APPLIED POLYMER MATERIALS(2022)
摘要
Hydrogels are interesting materials for application in biomedicine due to their outstanding properties (e.g., water retention, drug release, and biocompatibility). This work evaluates two series of phosphorus-based hydrogels as potential wounddressing candidates. The materials were synthesized via free-radical polymerization of bis[2-(methacryloyloxy)ethyl] phosphate (BMEP, >= 75 wt %) with (3-acryl amidopropyl)-trimethylammonium chloride solution (APTAC) or 2-acrylamido-2-methyl-1-propane sulfonic acid (AMPS). Due to optimized synthetic conditions, the materials displayed an unprecedented compressive elastic modulus (E') reaching up to 0.19 MPa, which represents a 1000-fold increase compared to previously reported materials. Furthermore, the hydrogels displayed good hydrolytic and enzymatic stability, cytocompatibility using bovine fibroblasts (BFs), and drug loading/release in woundlike pH conditions. In summary, this work demonstrates the potential of phosphorusbased hydrogels as drug-eluting wound-dressing materials.
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关键词
poly(phosphodiesters),poly(phosphates),hydrogels,wound dressing,drug delivery,cytocompatibility,mechanical properties
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