Long short-term memory model – A deep learning approach for medical data with irregularity in cancer predication with tumor markers

•Early cancer risk prediction tool powered by the largest to date real-world dataset of Tumor Biomarkers (TM).•The first study of model using time-series TM data, further improve the early cancer predictive performance of LSTM model.•The first study of semi-quantitative measurement of early cancer diagnosis by TM screening and clinical follow-ups.