EFFECT OF NON-SURGICAL PERIODONTAL TREATMENT ON LIPOXIN A(4) LEVELS IN PERIODONTITIS PATIENTS

The aim of this study was to determine the lipoxin A(4) (LXA(4)) in gingival crevicular fluid (GCF) and saliva in chronic periodontitis (CP) patients before and after non-surgical periodontal treatment (NSPT). A total of twenty subjects, ten patients with CP and ten healthy individuals were included in this study. Clinical measurements, GCF and saliva samples were obtained at the beginning and one month after NSPT. GCF and salivary LXA(4) were investigated by ELISA. Salivary LXA(4) were significantly higher in CP than in healthy subjects (p < 0.05), but no significant difference was observed after NSPT (p > 0.05). GCF LXA(4) were lower in CP and decreased after NSPT, but these differences were not significant (p > 0.05). However, GCF LXA(4) in post-treatment CP group were significantly lower than in healthy subjects (p < 0.05). Negative correlation was found between probing depth and GCF LXA(4) in CP group (r = -0.717; p < 0.05). Within the limitations of this study, LXA(4) might have a potential role in both the pathogenesis of periodontitis and the healing process.