Investigation of serum homocystein levels in patients with breast cancer

Objective: Scientific studies are continuing on many molecules in order to be used in the diagnosis of diseases. The fact that even one of these molecules can be used for diagnosis is very important for clinicians in diagnosing the disease. For this purpose, intensive studies continue on homocysteine and arginine. For these reasons, in this study, we aim to determine whether there is any change in homocysteine and arginine levels in the serum of blood samples of breast patients and to explain its relationship with breast cancer. Material Materials and Methods: We carried out our work in Selcuk University Faculty of Medicine Biochemistry Metabolism Laboratory. Our study included 20 controls, 20 breast Ca, 20 metastasis patients. Blood collected from breast cancer patients stored at -80 ° C until biochemical analysis is performed. Homocysteine and arginine levels measured in the sera obtained from the blood samples taken. The levels of proteins were measured at 470 nm in the NMRspectrophotometer. To measure homocysteine levels were injected into the mass spectrometer for chromatography. Results: In the evaluation, a statistical increase was observed in Arginine, Arginine / ADMA levels in patients with breast Ca, and Homocysteine levels in patients with metastases compared to the control group. When the breast cancer error group was compared with the metastasis group, the homocysteine level increased statistically, while the Arginine / ADMA level decreased statistically. Conclusion: Based on the results we obtained, it is thought that these markers can be used during the diagnosis and treatment of breast cancer patients.