Hsa_circ_0093884 bound to RNA-binding protein RPS3 ameliorates hepatocyte inflammation in anti-tuberculosis drug-induced liver injury by competitively activating SIRT1

Luming Yang,Lin Wang,Qinyan Tang, Yue Liu,Chunyan Meng,Shufeng Sun,Yingzhi Chong,Yiyang Zhang,Fumin Feng

International Immunopharmacology（2022）

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摘要

•hsa_circ_0093884 expression was downregulated in anti-tuberculosis drug-induced liver injury(ADLI).•hsa_circ_0093884 could inhibit the inflammatory in ADLI.•hsa_circ_0093884 could upregulate its host gene SIRT1 by bound to RNA-binding protein RPS3.

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关键词

Drug-induced liver injury,circRNA,Hsa_circ_0093884,SIRT1,RNA-binding protein

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