An Unprecedented FeMo6@Ce-Uio-66 Nanocomposite with Cascade Enzyme-Mimic Activity as Colorimetric Sensing Platform

Introducing the idea of integrated design and cascade activity into nanozyme, the novel integrated nanozymes (INAzymes), FeMo6@Ce-Uio-66 (FC-66(n)), were designed and synthesized by encapsulating iron-based polyoxometalates (FeMo6) into the ceria-based metal-organic framework (Ce-Uio-66). Due to the oxygen-driven reversible Ce3+/Ce4+ couple sites, the "Fenton-like" effect by iron centers, the "nanoscale proximity" effects by nanocages, and their synergistic effects, FC-66(n) as INAzymes exhibit elegant cascade enzyme-mimic activities (oxidase-, peroxidase-, and Fenton-like activity), which realizes INAzyme activities based on polyoxometalates based metal-organic framework (POMOFs). By employing dopamine (DA) detection as a model reaction, a high-efficient fluorescent "turning-on-enhanced" platform under near neutral conditions was established.