Modern possibilities of application Tc-99m-labeled prostate-specific membrane antigen ligands in prostate cancer

This article presents a modern possibilities and future path of prostate-specific membrane antigen (PSMA) radiopharmacuticals labeled by Tc-99m, that is the most popular isotope using in conventional nuclear medicine. The main advantages and disadvantages of SPECT/CT with these radiopharmaceuticals in different phases of prostate cancer continuum have been analyzed. Results of research diagnostic sensitivity of Tc-99m-PSMA SPECT/CT including comparison with Ga-68-PSMA PET/CT and conventional modality such as MRI and bone scan are presented. The prerequisites of application Tc-99m-labeled PSMA ligands in PSMA-guided surgery, methodology of PSMA-guided surgery and foreign authors application experience are presented in this article too.