Modern possibilities of application Tc-99m-labeled prostate-specific membrane antigen ligands in prostate cancer
Cancer Urology(2021)
Abstract
This article presents a modern possibilities and future path of prostate-specific membrane antigen (PSMA) radiopharmacuticals labeled by Tc-99m, that is the most popular isotope using in conventional nuclear medicine. The main advantages and disadvantages of SPECT/CT with these radiopharmaceuticals in different phases of prostate cancer continuum have been analyzed. Results of research diagnostic sensitivity of Tc-99m-PSMA SPECT/CT including comparison with Ga-68-PSMA PET/CT and conventional modality such as MRI and bone scan are presented. The prerequisites of application Tc-99m-labeled PSMA ligands in PSMA-guided surgery, methodology of PSMA-guided surgery and foreign authors application experience are presented in this article too.
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Key words
prostate cancer, salvage lymph node dissection, radioguided surgery, prostate-specific membrane antigen, Tc-99m-PSMA, SPECT/CT, PET/CT
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