Nickel‐Catalyzed Aminofluoroalkylation of Alkenes: Access to Difluoroalkylated N‐Containing Heterocyclic Compounds

Xiaoyi Fu,Tianyu Zhang,Jingjing Wu,Yijie Sun,Fanhong Wu

European Journal of Organic Chemistry（2022）

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摘要

A nickel‐catalyzed aminofluoroalkylative cyclization of unactive alkenes with iododifluoromethyl ketones was developed to construct versatile difluoroalkylated Nitrogen‐containing heterocycles including aziridines, pyrrolidines and piperidines in moderate to high yields. This method features a broad substrate scope and has been demonstrated on gram scale.

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关键词

Aziridines,Cyclization,N-Containing heterocycles,Nickel catalysis,Synthetic methods

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