Dimethyl fumarate (DMF) inhibits proliferation and migration and induce cell death in solid tumor cells

Marlen Michalski,Anne Schroeder, Manuela Gunkel,Martina Müller-Schilling,Karsten Gülow

Zeitschrift für Gastroenterologie38. Jahrestagung der Deutsche Arbeitsgemeinschaft zum Studium der Leber（2022）

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摘要

Introduction Recently, we have shown in mouse models that dimethyl fumarate (DMF) treatment led to reduced metastasis formation and induction of cell death in malignant cells e. g. T-cell lymphoma. Solid tumors including hepatocellular carcinoma a characterized by a rather high ability to form metastasis. Therefore, we analyzed the effects of DMF on solid tumors.

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dimethyl fumarate,solid tumor cells,cell death,dmf

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