Cdk5 as a possible new target in biliary tract cancer: preliminary in-situ findings

Fabian Wilhelm,Eckhard Klieser,Bettina Neumayer,Paul Winkelmann,Tarkan Jäger,Johanna Pachmayr,Maximilian Ardelt,Petra Huber-Cantonati,Celina Ablinger, Irina Pancis,Markus Ritter,Tobias Kiesslich,Christian Mayr,Daniel Neureiter

Zeitschrift für Gastroenterologie38. Jahrestagung der Deutsche Arbeitsgemeinschaft zum Studium der Leber（2022）

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Abstract

Objective Biliary tract cancer (BTC) still shows a poor survival prognosis dueto the lack of sufficient therapies and the observed chemoresistance. Cyclin-dependent kinases (Cdks) have gained increasing interest as potential cancertherapeutic targets in the last few years. The current study evaluates the proteinexpression of Cdk5 and its biomarker potency in a clinico-pathologicallywell-characterized patient cohort of BTCs.

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Key words

biliary tract cancer,in-situ

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