Boosting the Sensitivity of the Nanopore Field-Effect Transistor to Translocating Single Molecules

Nano-scaling of metal-oxide-semiconductor (MOS) field-effect transistors (FETs) is exploited to benefit the interdisciplinary field of single-molecule biosensing. While single-molecule DNA sequencing is done successfully by ionic current sensing through nanopores, the unambiguous characterization of more complex single biomolecules, such as fast translocating proteins, remains challenging with exi...