UPLC-MS/MS method for the quantification of MCI-77, a novel sigma-1 receptor ligand, and its application to pharmacokinetic studies

Raluca Popa,Shyam H Kamble,Raju S Kanumuri,Tamara I King,Erin C Berthold,Sebastiano Intagliata,Abhisheak Sharma,Christopher R McCurdy

Journal of Chromatography B（2022）

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摘要

•An UPLC-MS/MS method was developed to quantify the novel compound MCI-77.•The method was validated in accordance with FDA guidelines.•The method was used to analyze samples from pharmacokinetics studies in mice.

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关键词

Sigma-1 receptor,UPLC-MS/MS,Method validation,Pharmacokinetics

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