Role of IGF-1 in neuroinflammation and cognition deficits induced by sleep deprivation

Yahui Wan, Wei Gao,Kaili Zhou,Xuan Liu,Wei Jiang,Rong Xue,Wei Wu

Neuroscience Letters（2022）

引用 9|浏览6

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摘要

•Sleep deprivation results in IGF-1 down-regulation in the hippocampus.•IGF-1 can attenuates the cognitive decline after sleep deprivation.•IGF-1 modulates the inflammatory response and apoptosis by regulating the PI3/AKT/GSK-3β pathway after sleep deprivation.

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关键词

Sleep deprivation,IGF-1,Inflammation,Cognitive impairment,Apoptosis

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