Association between proton pump inhibitors and severe hematological toxicity in patients receiving pemetrexed-based anticancer treatment: The prospective IPPEM study

Florian Slimano,Antoine Le Bozec,Amélie Cransac,Pascal Foucher, François Lesauvage,Bertrand Delclaux,Anne Dory,Bertrand Mennecier,Benjamin Bertrand, Marie-Christine Gubeno-Dumon,Sylvain Dukic,Céline Mongaret,Olivier Bouché,Dominique Hettler,Mathieu Boulin,Maxime Dewolf,Lukshe Kanagaratnam

Lung Cancer（2022）

引用 3|浏览15

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摘要

•Hematological toxicity of pemetrexed is more severe with PPI use.•Clinical consequences of pemetrexed toxicity are more frequent with PPI use.•When starting pemetrexed, PPI should be deprescribed when possible.

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关键词

Pemetrexed,Proton pump inhibitors,Drug interactions,Organic anion Transporters-3,Hematological toxicity

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