Does the volume and constitution of cardiopulmonary bypass priming fluids affect blood loss post cardiac surgery in children?

Pediatric patients, especially neonates and infants, undergoing cardiac surgery, are at particularly high risk for developing surgical bleeding. After separation from cardiopulmonary bypass (CPB), excessive bleeding in children frequently requires the administration of large volumes of blood products to achieve hemostasis. In the operating room (OR), this period of bleeding and transfusion of blood products is associated with hemodynamic instability, prolonged surgery time, hypothermia, and the need for escalating inotropic support.