Design and multi-objective optimization of reactive-extractive dividing wall column with organic Rankine cycles considering safety

•The reactive-extractive dividing wall column configuration is proposed for the separation of ethyl acetate/ethanol/water.•The waste heat of reactive-extractive dividing wall column process is recovered via organic Rankine cycles.•A multi-objective optimization approach considering safety is investigated.•The organic Rankine cycle assisted reactive-extractive dividing wall column processes have better economic performance.