RISK FACTORS FOR DEVELOPMENT OF PROSTATE CANCER IN PATIENT WITH INFLAMMATORY BOWEL DISEASE (IBD)

Abstract BACKGROUND Prostate cancer (PC) is a 2nd leading cause of cancer death in the USA among men. We aim to investigate incidence, characteristics, and risk factors for PC in patients diagnosed with Inflammatory bowel disease (IBD) using Cerner Health Facts, a national longitudinal database representing approximately 69 million patients. METHODS All male patients over 40 years of age with IBD were included in our analysis. Our primary endpoint was development of PC, specified by ICD coding. Patient characteristics were evaluated as potential risk factors for development of PC using multivariable regression built using all variables with p<0.1 on univariable analysis. RESULTS Overall, 2.23% patients with IBD developed prostate cancer (992/44,551). Mean age was 59.7±12.7 years and 9.65% (04,297/44,551) of patients were obese. In terms of race, 82.9% (36,929/44,551) were white and 7.8% (3,470/44,551) were African American. 94.9% (41829/44,551) received care at an acute care facility and 83.7% (37,266/44,551) received care at an urban facility. On multivariable regression, the risk factors associated with higher risk of prostate cancer include diabetes (odds ratio OR 1.20), obesity (OR 1.22), age (OR 1.07), family history of prostate cancer (OR 6.04), African American race (OR 2.00), and married status (OR 1.43). Factors that decreased risk of pancreatic cancer include other race (OR 0.70; 95% CI 0.53-0.92), and presentation at acute facility (OR 0.59; 95% CI 0.46-0.76). Factors not found to be associated with high risk of PC in our study includes sexually transmitted disease, alcohol use disorder, smoking, presentation at teaching facility, and facility size/type (Table 1). The most protective variable against PC was presentation at acute facility (OR 0.59), other-race (OR 0.70). Table 1 contains our univariable analysis and multivariable regression model with 95% confidence intervals; 6 variables were predictive for PC and 2 variables were protective against PC. CONCLUSION We describe risk factors for development of PC from IBD. In this longitudinal national database study of patient with diagnosed IBD – age, diabetes, obesity, married status, family history of prostate cancer, and African American race were noted to be associated with high risk of developing prostate cancer. Careful evaluation and follow up is advised for IBD patients.