Bevacizumab’s Association With a Decreased Risk of Brain Metastases in ECOG-ACRIN E1505, a Phase 3 Randomized Trial of Adjuvant Chemotherapy With or Without Bevacizumab in Surgically Resected NSCLC

John M Varlotto,Yating Wang,Zhuoxin Sun,Heather A Wakelee,Suresh Ramalingam,Joan Schiller

JTO clinical and research reports（2022）

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摘要

The addition of bevacizumab to chemotherapy was associated with reduction in brain recurrences, but not ECR. Brain metastases whether isolated or not are associated with a lower median survival than ECR and unlike ECR are not associated with traditional staging variables.

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关键词

Brain metastases,Non–small cell lung cancer,Adjuvant therapy,Bevacizumab

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