Planning benchmark study for SBRT of liver metastases: Results of the DEGRO/DGMP working group stereotactic radiotherapy and radiosurgery

ABSTRACT

Purpose

To investigate, if liver SBRT treatment planning can be harmonized across different treatment planning systems, delivery techniques and institutions by using a specific prescription method and to minimize the knowledge gap concerning inter-system and inter-user differences. To provide best practice guidelines for all used techniques.

Methods

A multiparametric specification of target dose (GTV_D50%, GTV_D0.1cc, GTV_V90%, PTV_V70%) with a prescription dose of GTV_D50% = 3 × 20 Gy and OAR limits were distributed with CTs and structure sets from three liver metastases patients. Thirty-five institutions provided 132 treatment plans using different irradiation techniques. These plans were first analyzed for target and OAR doses. Four different renormalization methods were performed (PTV_Dmin, PTV_D98%, PTV_D2%, PTV_Dmax). The resulting 660 treatments plans were evaluated regarding target doses in order to study the effect of dose renormalization to different prescription methods. A relative scoring system was used for comparisons.

Results

GTV_D50% prescription can be performed in all systems. Treatment plan harmonization was overall successful with standard deviations for D_max, PTV_D98%, GTV_D98% and PTV_Dmean of 1.6 Gy, 3.3 Gy, 1.9 Gy and 1.5 Gy, respectively. Primary analysis showed 55 major deviations from clinical goals in 132 plans, while in only <20% of deviations GTV/PTV dose was traded for meeting OAR limits. GTV_D50% prescription produced the smallest deviation from target planning objectives and between techniques, followed by the PTV_Dmax, PTV_D98%, PTV_D2% and PTV_Dmin prescription. Deviations were significant for all combinations but for the PTV_Dmax prescription compared with GTV_D50% and PTV_D98%. Based on the various dose prescription methods, all systems significantly differed from each other, while GTV_D50% and PTV_D98% prescription showed the least differences between the systems.

Conclusions

This study showed the feasibility of harmonizing liver SBRT treatment plans across different treatment planning systems and delivery techniques when a sufficient set of clinical goals is given.