Application of polydopamine fibers mat for simultaneous detection of multi-class drug residues in various animal-original foods

Polydopamine/polystyrene fibers mat (PDA-PS FsM) was prepared as a novel solid phase extraction (SPE) adsorbent for the simultaneous extraction of multi-class veterinary drug residues in animal-original foods. On this basis, a screening method for the determination of 18 veterinary drug residues in 8 classes by UPLC-MS/MS was established. PDA-PS FsM was confirmed to have good adsorption-desorption performance. By comparing the matrix effect before and after SPE, it was proved that PDA-PS FsM had significant matrix removal ability. The whole sample preparation process was less than 5 min, only 20 mg PDA-PS FsM and 2.5 mL of organic solvent were needed. The limits of detection of the target analytes ranged from 0.1 to 3.2 μg kg−1, and the recoveries ranged from 92.59% to 102.86%, with the intra-day and inter-day relative standard deviations of 2.11%–10.57%, revealing satisfactory accuracy and precision. Finally, the practicability of the method was evaluated.