家族内2次感染防御率からみた, FHA Predominant Acellular Pertussis Vaccineの効果

To evaluate the vaccine efficacy of FHA predominant acellular pertussis vaccine, which has been in clinical use since 1981 in Japan, the author recently made a retrospective study by the questionnaire from of secondary pertussis attacks throughfamily contact in 96 children with pertussis diagnosed in the periodfrom January 1981 through August 1986.Number of the answere to the questinnaire were 75 patients.Secondary pertussis attacks throughfamily contact were found in 19 (65.5%) of 29 siblings not immuniz with pertussis vaccine.On the other hand of the siblings immunized with FHA predominant acellular vaccine (Takeda), 13 were exposed to pertussis throughfamily contact and secondary attack was seen in only one of them.The present survey revealed anefficacy rate of 88.3%for FHA predominant acellular pertussis Takeda's vaccine. A simultanous survey of whole cell pertussis vaccine reveald 79.3%.