Synthesis and Biology of Substituted 3′-Phenyl Taxol Analogues.
ChemInform(1995)
摘要
Abstract A series of substituted 3′-phenyl taxol analogues, directed by the Topliss Operational Scheme, were synthesized and evaluated for their biological activity. The novel analogues were prepared from baccatin III and N-acyl β-lactams. Evaluation in the microtubule assembly assay and for cytotoxicity against B16 melanoma cells illustrated a modest influence of aromatic substitution on bioactivity.
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关键词
cheminform abstract,synthesis
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