Relationship Between Chemical Structure and Antileishmanial Effect of Sinefungine Analogues.

Abstract The synthesis of various analogues of sinefungin (l), having structures 2-5, has been developed by means of an original approach which uses radical chemistry. The study of their biological activities revealed that for the antileishmanial effect of sinefungin, the presence of the amino group at C-6′ in the (S)-configuration and the presence of the carboxyl group at C-9′ are necessary.