Synthesis and Antibacterial Activity of Cephalosporins Having Hydroxamic Acid at C‐7 Position.

Min Gyu Kim,Jae Chul Jung,Moo Je Sung,Young Key Choi,Sang Geun An,Sang Joon Lee,Goo Yoon,Myung Hwan Park

ChemInform（1996）

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摘要

Abstract The synthesis and in vitro activity of cephalosporins with hydroxamic acid at the 7-position are described. Anti-pseudomonal activity of the compound 11a was shown to be comparable to that of ceftazidime. Especially, the compound 11a exhibited good activity against Gram-positive bacteria including Streptococcus pneumoniae and Staphylococcus aureus .

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关键词

cephalosporins,hydroxamic acid,antibacterial activity,cheminform abstract,synthesis

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