New Reagents for Controlled Release of Nitric Oxide. Structure‐ Stability Relationships.

Abstract The synthesis and structure-stability relationships of a series of novel FK409 derivatives ( 1 , 2 , and 3 ) are described. The rates of decomposition in aqueous solution (pH 8.0, 30 °C) were parallel with those of spontaneous NO release measured by ESR spectroscopy using carboxy-PTIO. The compounds can cover a wide range of NO releasing rates by appropriate modification of the molecule.