BMS-187257, a Potent, Selective, and Novel Heterocyclic β3 Adrenergic Receptor Agonist.

Abstract Novel heterocyclic β 3 adrenergic receptor agonists 2 were prepared and evaluated for their ability to bind to human β 1 , β 2 , and β 3 adrenergic receptors. Stimulatory effects on the β 3 adrenergic receptor were also measured. BMS-187257 ( 4b ) was found to be a potent and selective β 3 agonist.