Synthesis and Biological Evaluation of New Tetrahydronaphthalene Derivatives as Thromboxane Receptor Antagonists.

Bernard Cimetiere,Thierry Dubuffet,Olivier Muller,Jean-Jacques Descombes,Serge Simonet,Michel Laubie,Tony Verbeuren,Gilbert Lavielle

ChemInform（1998）

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摘要

New polysubstituted tetrahydronaphthalene derivatives were prepared as thromboxane receptor (TP-receptor) antagonists. Within this series of compounds S 18886 has been identified as an orally active, highly potent antagonist with a very long duration of action in different species.

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new tetrahydronaphthalene derivatives,thromboxane receptor antagonists,cheminform abstract

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