OShnscc:a novel user-friendly online survival analysis tool for head and neck squamous cell carcinoma based on RNA expression profiles and long-term survival information

Head and neck squamous cell carcinoma (HNSCC), as the most common type (>90％) of head and neck cancer, includes various epithelial malignancies that arise in the nasal cavity, oral cavity, pharynx, and larynx. In 2020, approximately 878000 new cases and 444000 deaths linked to HNSCC occurred world-wide (Sung et al., 2021). Due to the associated fre-quent recurrence and metastasis, HNSCC patients have poor prognosis with a five-year survival rate of 40％–50％(Jou and Hess, 2017). Therefore, novel prognostic biomarkers need to be developed to identify high-risk HNSCC patients and improve their disease outcomes.