Balsalazide Exposure During the Development of Fertilizing Sperm May Be Associated With Offspring Birth Defects

Maarten J Wensink,Sarah E Streett,Per Damkier,Rune Lindahl-Jacobsen,Jens Kjeldsen,Michael L Eisenberg

INFLAMMATORY BOWEL DISEASES（2022）

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摘要

Lay Summary We report an association between balsalazide exposure during the development of fertilizing sperm and birth defects in offspring. Exposed offspring were approximately 8 times more likely to have a birth defect. There were no pre-existing reasons to suspect such a relationship, which should be confirmed in other data.

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Balsalazide, birth defects, major malformations, congenital anomalies, paternal effect

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