Dibasic Inhibitors of Human Mast Cell Tryptase. Part 3. Identification of a Series of Potent and Selective Inhibitors Containing the Benzamidine Functionality.

Dener Jeffrey M,Kenneth D. Rice,William S Newcomb,Vivian R. Wang,Wendy B. Young,Gangloff Anthony R,Elaine Y.-L Kuo,Lynne Cregar,Daun Putnam,Martin Wong

ChemInform（2001）

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摘要

A survey of charged groups and linkers for a series of symmetrical and unsymmetrical dibasic inhibitors is described, leading to several classes of potent and selective inhibitors. In particular, the benzamidine functionality was identified as the most potent charged group investigated.

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