A Study on the Toxicity and Mutation of Trichloroacetaldehyde

Objective To determine the toxicity and mutagenic effect of trichloroacetaldehyde.[Methods]Acute toxicity test,mutation test and single-cell gel electrophoresis(SCGE)were used.[Results]LD 50 for trichloroacetaldehyde by intragastric and dermal administration in male and female rats are1000mg/kg,681mg/kg and1470mg/kg,1210mg/kg,respectively.The acute skin ir-ritation test and acute eye irritation test in rabbits showed that the tested chemical has meddle irritation.The micronucleus test at a dose of160mg/kg,Ames test at1mg/plate and SCGE of lymphocytes in mice and human were positive.[Conclusion] Trichloroacetalde-hyde shows a lowtoxicity,mutation tests are positive.