Discovery of a Novel, Potent and Selective Human β3-Adrenergic Receptor Agonist.

Yutaka Nakajima,Hitoshi Hamashima,Kenichi Washizuka,Yasuyo Tomishima, Hiroaki Ohtake,Emiko Imamura,Toshiko Miura,Hiroshi Kayakiri,Masayuki Kato

ChemInform（2005）

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摘要

Abstract The discovery of a novel, potent and selective β3-adrenergic receptor (AR) agonist is described. SAR studies demonstrated the structural requirements for activity and selectivity. Compound 1c, which showed good β3-AR activity and selectivity, was identified and pharmacokinetics were investigated.

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