Experimental study on the osteointegration of nanophase hydroxyapatite biograde-coated implants

OBJECTIVE To study the osseointegration of the nanophase hydroxyapatite biograde-coated implants and host bone. METHODS Nanophase hydroxyapatite biograde-coated implants, hydroxyapatite biograde-coated implants and noncoated Ti-6Al-4V implants were inserted into both femoral of Beagle canines the tissue response, dynamic osteogensis and SEM were studied at 4, 8 and 12 weeks. RESULTS The degradation of nanophase hydroxyapatite was slower than hydroxyapatite, dynamic osteogensis and the form of osteoblast were better than the control groups. CONCLUSION The biological reaction of Nanophase hydroxyapatite biograde-coated implants is better than hydroxyapatite coated implant.