Mp-15.11

The risk of developing muscle-invasive disease for a high-risk superficial bladder cancer patient is up to 50%. Identification of those patients at risk for progression remains an unsolved problem. A suggested prognosticator is presence of mutations in the p53 tumour suppressor gene. In this study the value of a p53 mutation, demonstrated by mutation analysis is determined in a clinically selected group of high risk superficial bladder cancer patients.