Clinical application of clomiphene citrate combined with progynova in intrauterine insemination(IUI)

Objective To observe therapeutic effect of combination of clomiphene citrate with Progynova in intrauterine insemination(IUI) and to investigate the influential factors of clomiphene so as to increase the success rate of IUI.Methods The data from 50 patients who underwent 56 cycles of IUI treatment regime were analyzed retrospectively.All patients received clomiphene ciatrate(CC)+ Progynova /IUI.The endometrial thickness(Em),follicle numbers,serum estradiol(E_2) levels on the administration day of human chorianic gonadotropin(hCG) and clinical pregnancy outcomes of the patients with different ages were summarized.Results In 57 cycles of clamiphene + Progynove/ IUI treatment,there were 6 pregnancies,of which 4 pregnancies were ongoing.Among the three groups,in fertility age,body mass index,basic serum FSH,luteinizing hormone(LH),E_2,there were no differences(P0.05).After ovulation induction,in the follicular number on the administration day of hCG there was no difference between CC+ Progynova /IUI group and Em in CC+ Progynova /IUI group(P0.01).The clinic pregnancy rate was 12% and the cycle pregnancy rate was 10.7%,of which,1 case was ectopic pregnancy,and 1 case had early abortion.Conclusion CC+ Progynova /IUI could increase endometrial thinckness,which contributes to implantation of embryo.In combination with IUI,better pregnancy outcomes could be gained.