Solitary plasmacytoma of clavicle, a case report and literature review

Objective To study the clinicopathologic and immunohistochemical features,diffential diagnosis and treatment of solitary plasmacytoma of the bone.Methods Light microscopic and immunohistochemical results of solitary plasmacytoma of clavicle in one patients and related literature was reviewed.Results Microscopically,the tumor cells were marked atypia with an eccentric nuclei, conjugate nuclear and polynuclear giant tumour cells were seen. Before operation the tumor had infiltrated surrounding soft tissue and formed a mass; after operation the tumor cells spreaded quickly. Immunohistochemically, It was positive for VS38C andκ, Ki-67 was strongly positive.Conclusion Bone solitary plasmacytoma is rare. Clinical presentation and pathological features of this patients is even more special, which should be distinguished from diffuse large B-cell lymphoma, anaplastic large cell lymphoma and poorly differentiated carcinoma.