The Mannich-Type Reaction Between N,O-Acetals and Carbon Nucleophiles under Solvent-Free Conditions.

The Mannich-type reaction for 1 -methoxycarbonyl- or 1 -benzyloxy-carbonyl-2-methoxylpyrrolidine with carbon nucleophiles such as acetylacetone, methyl acetoacetate, dimethyl malonates, benzoylacetone, dibenzoylmethane, or cyclohexane-1, 3-dione proceeded by acid catalysis under solvent-free conditions with more efficiency than that in dichloromethane.